Protein profile of exosomes from trabecular meshwork cells
نویسندگان
چکیده
منابع مشابه
Induction of trabecular meshwork cells from induced pluripotent stem cells.
PURPOSE Loss or dysfunction of trabecular meshwork (TM) cells has been associated with the development of pathologically elevated IOP, and it is conceivable that replacement of damaged TM cells could restore function to the TM. We propose that the use of TM-like cells derived from induced pluripotent stem cells (iPSCs) created from a patient's own dermal fibroblasts offers the best solution to ...
متن کاملMultipotent stem cells from trabecular meshwork become phagocytic TM cells.
PURPOSE To isolate and characterize stem cells from human trabecular meshwork (TM) and to investigate the potential of these stem cells to differentiate into TM cells. METHODS Human trabecular meshwork stem cells (TMSCs) were isolated as side population cells by fluorescence-activated cell sorting or isolated by clonal cultures. Passaged TMSCs were compared with primary TM cells by immunostai...
متن کاملsCD44 internalization in human trabecular meshwork cells.
PURPOSE To determine whether soluble CD44 (sCD44), a likely biomarker of primary open-angle glaucoma (POAG), is internalized in cultured human trabecular meshwork (TM) cells and trafficked to mitochondria. METHODS In vitro, 32-kD sCD44 was isolated from human sera, biotinylated, and dephosphorylated. TM cells were incubated for 1 hour at 4°C with biotinylated albumin (b-albumin), biotin-label...
متن کاملHyaluronan synthase in trabecular meshwork cells.
BACKGROUND/AIMS Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated. METHODS Cultured bovine trabecular meshwork cells (BTMCs) were used. HAS expression in...
متن کاملGene expression profile of human trabecular meshwork cells in response to long-term dexamethasone exposure.
PURPOSE Topical use of dexamethasone has long been associated with steroid induced-glaucoma, although the mechanism is unknown. We applied a strict filtering of comparative microarray data to more than 18,000 genes to evaluate global gene expression of cultured human trabecular meshwork cells in response to treatment with dexamethasone. METHODS Three human trabecular meshwork cell primary cul...
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ژورنال
عنوان ژورنال: Journal of Proteomics
سال: 2011
ISSN: 1874-3919
DOI: 10.1016/j.jprot.2011.02.024